EGFR-IN-60 - CAS 2699877-43-3

EGFR-IN-60 is an effective, orally active, safe antitumor agent. EGFR-IN-60 significantly inhibits EGFRWT (IC50: 83 nM), EGFRT790M (IC50: 26 nM), EGFRL858R (IC50: 53 nM) and JAK3 (IC50: 69 nM) . IN-60 inhibited H1975 cells carrying the EGFRT790M mutation (IC50: 1.32 μM) and A431 cells overexpressing EGFRWT (IC50: 4.96 μM) . EGFR-IN-60 increased the Bax/Bcl-2 ratio, which induced apoptosis induction and cell death.

Apoptosis, EGFR, Others

Apoptosis, JAK/STAT signaling, Angiogenesis, Others, Tyrosine Kinase/Adaptors

2699831

C28H28Cl2N6O

535.47

O=C1C=2C(C3=C(NC2CC(C)(C)C1)N=CN(N=CC4=CC=C(N(C)C)C=C4)C3=N)C5=C(Cl)C(Cl)=CC=C5

-20°C

Ice Packs

Small Compound