EGFR-IN-89 - CAS 2413029-40-8

EGFR-IN-89 (compound 13k) is a fourth-generation inhibitor that selectively targets EGFR mutations, showing potent activity with an IC50 of 10.1 nM against Del19/T790M/C797S mutations, and demonstrating greater selectivity for mutant forms over wild type [1].

EGFR

Angiogenesis, Tyrosine Kinase/Adaptors, JAK/STAT signaling

2412981

C26H31FN8O2S

538.64

N(C1=C2C(=NC(NC3=CC(F)=C(C=C3)N4CCN(CC)CC4)=N1)NC=C2)C5=C(N(S(C)(=O)=O)C)C=CC=C5

-20°C

Ice Packs

Small Compound