EGFR-IN-91 - CAS 3032113-20-2

EGFR-IN-91 (compound 9) is an orally active EGFR inhibitor capable of crossing the blood-brain barrier. It effectively inhibits EGFRL858R/C797S and EGFRexon 19del/C797S, leading to tumor regression in patient-derived xenograft (PDX) mouse models. EGFR-IN-91 shows potential for inhibiting locally advanced and metastatic non-small cell lung cancer (NSCLC) driven by EGFR mutations.

EGFR

Angiogenesis, JAK/STAT signaling, Tyrosine Kinase/Adaptors

3032091

C22H25ClFN5O3

461.92

FC=1C(Cl)=CC=CC1NC=2N=CN=C3C=C(OC)C(OCCON4CCN(C)CC4)=CC32

-20°C

Ice Packs

Small Compound