EGFR kinase inhibitor 1 - CAS 2413958-04-8

EGFR kinase inhibitor 1 is a potent inhibitor of EGFR that acts on WT (IC50: 37 nM), l885R/T790M (IC50: 1.7 nM), and L858R/T790M/C797S (IC50>300 nM) . It is capable of blocking the cell cycle in G0/G1 phase, inducing apoptosis, and has an inhibitory effect on cell metastasis. Additionally, EGFR kinase inhibitor 1 exhibits anti-proliferative and anti-tumor effects.

Apoptosis, EGFR, Others

JAK/STAT signaling, Others, Tyrosine Kinase/Adaptors, Apoptosis, Angiogenesis

2413958-04-8

C30H31N7O2

521.61

N(C(C=C)=O)C1=C(C=C(OC)C(NC=2N=C(C=CN2)C=3C=4C(N(C)C3)=CC=CC4)=C1)N5C(CN(C)C)=CC=C5

-20°C

Ice Packs

Small Compound