EGFR kinase inhibitor 4 - CAS 2922402-05-7

EGFR Kinase Inhibitor 4 (Compound 4) acts as a bivalent ATP-allosteric inhibitor targeting EGFR, with a potent inhibitory effect (IC 50: 1.8 nM) on mutant EGFR (LRTMCS) . It is primarily utilized in the study of non-small cell lung cancer (NSCLC) [1].

EGFR

Tyrosine Kinase/Adaptors, JAK/STAT signaling, Angiogenesis

2922402-05-7

C40H34N8O4

690.75

C(C)C=1NC(=C(N1)C2=CC(NC(=O)C3=C4C(NC=5C(C(=O)N4)=CC=CC5)=CC=C3)=CC=C2)C=6C=C(NC7=C(OC)C=CC(NC(C=C)=O)=C7)N=CC6

-20°C

Ice Packs

Small Compound