EGFR T790M/L858R-IN-7 - CAS 3032760-90-7

EGFR T790M/L858R-IN-7 (Compound 72), a novel pyrimidine compound, exhibits high efficacy in inhibiting the EGFR T790M and L858R mutations, with a 93% inhibition rate at 0.05 μM. It achieves its inhibitory action by specifically binding to the kinase domain of EGFR, which prevents phosphorylation activity [1].

EGFR

Tyrosine Kinase/Adaptors, Angiogenesis, JAK/STAT signaling

3032760-90-7

C27H29N7O4

515.56

N(C=1N=C(N2C=3C(C=C2)=CC=CN3)C=CN1)C4=C(OC)C=C(OC)C(NC(/C=C/CN5CCOCC5)=O)=C4

-20°C

Ice Packs

Small Compound