EGFR/VEGFR2-IN-3 - CAS 710972-61-5

EGFR/VEGFR2-IN-3 (compound 9) is an effective inhibitor of EGFR and VEGFR-2, demonstrating IC50 values of 0.129 μM for EGFR, 0.142 μM for VEGFR-2, and 3.428 μM for COX-2. This compound exhibits cytotoxic properties and induces cell apoptosis (apoptosis) as well as cell cycle arrest at the G2/M phase.

Apoptosis, VEGFR, EGFR

Tyrosine Kinase/Adaptors, JAK/STAT signaling, Apoptosis, Angiogenesis

710906

C24H20ClN5O2S2

510.03

O=C(NNC(=S)NC1=CC=C(C=C1)C)CSC2=NC=3C=CC=CC3C(=O)N2C4=CC=C(Cl)C=C4

-20°C

Ice Packs

Small Compound