Eggmanone - CAS 505068-32-6

Eggmanone (EGM1) is a potent, selective phosphodiesterase 4 (PDE4) antagonist, exhibiting an IC50 of 72 nM specifically for PDE4D3. It shows 40- to 50-fold greater selectivity for PDE4D3 over other phosphodiesterases. The mechanism of action involves PDE4 selective antagonism by Eggmanone, which activates protein kinase A, culminating in the blockade of the Hedgehog (Hh) signaling pathway [1].

Others, PDE

Others, Metabolism

505030

C20H20N2O2S3

416.58

CC(=C)Cn1c(SCC(=O)c2cccs2)nc2sc3CCCCc3c2c1=O

-20°C

Ice Packs

Small Compound