EHNA - CAS 51350-19-7

EHNA is a potent and selective dual inhibitor of cyclic nucleotide phosphodiesterase 2 (PDE2) (IC50 = 4 μM) and adenosine deaminase (ADA) . It exhibits concentration-dependent inhibition of cGMP-stimulated PDE2 activity, with IC50 values of 0.8 μM in humans and 2 μM in porcine myocardium, but shows limited inhibition on unstimulated PDE2. EHNA is involved in modulating various pharmacological responses, such as antiviral, antitumor, and antiarrhythmic effects.

Influenza Virus, Adenosine Deaminase, PDE

Microbiology/Virology, Metabolism

51324

C14H23N5O

277.37

[C@H](CCCCCC)([C@@H](C)O)N1C=2C(N=C1)=C(N)N=CN2

-20°C

Ice Packs

Small Compound