ELA-21 (human) - CAS 2245073-05-4

High affinity apelin receptor agonist. Binds apelin receptors in left ventricle from normal and pulmonary arterial hypertensive (PAH) hearts (pKi values are 9.31 and 9.46, respectively) . Bioactive fragment of ELA-32. Inhibits forskolin-induced cAMP production and stimulates β-arrestin recruitment in vitro.

Apelin receptor, Arrestin

GPCR/G Protein

2245073-05-4

C112H184N40O25S3

2587.12

C(N[C@H](C(=O)N1[C@H](C(O)=O)CCC1)CC2=CC=CC=C2)(=O)[C@H]3N(C([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC4=CN=CN4)NC([C@@H](NC(=O)[C@H]5N(C([C@@H](NC(=O)[C@H]6NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC([C@@H](NC([C@H](CC7=CN=CN7)NC([C@@H](NC([C@@H](NC([C@H](CC(C)C)N)=O)CCCNC(=N)N)=O)CCCCN)=O)=O)CC(N)=O)=O)CSSC6)CCSC)=O)CCC5)CC(C)C)=O)=O)CO)=O)CCCNC(=N)N)=O)C(C)C)=O)CCC3

-20°C

Ice Packs

Peptide