Ellipticine quinone - CAS 73326-98-4

Ellipticine quinone, also known as NSC-383230, is a Drp1 inhibitor. rpitor1 and Drpitor1a inhibited the GTPase activity of Drp1 without inhibiting the GTPase of dynamin 1. Ellipticine quinone showed greater potency than the current std. Drp1 GTPase inhibitor, mdivi-1, (IC50 for mitochondrial fragmentation are (0.06, and 10 μM, resp.) . Ellipticine quinone suppressed lung cancer tumor growth in a mouse xenograft model. Ellipticine quinone also inhibited mitochondrial ROS prodn., prevented mitochondrial fission, and improved right ventricular diastolic dysfunction during IR injury.

Dynamin, Reactive Oxygen Species, Others

Metabolism, Others, NF-κB, Cytoskeletal Signaling, Immunology/Inflammation

73224

C15H8N2O2

248.24

O=C1C2=C(C(=O)C=3C1=CN=CC3)NC=4C2=CC=CC4

-20°C

Ice Packs

Small Compound