Emavusertib Maleate - CAS 2376399-39-0

Emavusertib Maleate (also known as CA-4948) is a potent inhibitor of IRAK4/FLT3, demonstrating antitumor activity. In ABC DLBCL and AML cell lines, CA-4948 exhibited strong cellular activity. It showed moderate to high selectivity in a test against 329 kinases and demonstrated good oral bioavailability in ADME and PK profiles, with effective absorption in mice, rats, and dogs. In relevant tumor models, CA-4948 achieved over 90% tumor growth inhibition and showed excellent correlation with in vivo PD modulation.

IRAK, NF-κB, MyD88, FLT, Apoptosis

Apoptosis, Tyrosine Kinase/Adaptors, Angiogenesis, Immunology/Inflammation, NF-κB

2376360

C28H29N7O9

607.57

C(=C\C(O)=O)\C(O)=O.N(C(=O)C=1N=C(OC1)C=2C=C(C)N=CC2)C3=C(N=C4C(=C3)OC(=N4)N5CCOCC5)N6CC[C@@H](O)C6

-20°C

Ice Packs

Small Compound