Emavusertib Tosylate - CAS 2376399-41-4

Emavusertib Tosylate (also known as CA-4948) is a potent inhibitor of IRAK4/FLT3 with demonstrated antitumor activity. In cell lines such as ABC DLBCL and AML, CA-4948 exhibits strong cellular efficacy. Among 329 evaluated kinases, it shows medium to high selectivity. The compound has excellent oral bioavailability and favorable pharmacokinetic properties in ADME and PK profiles. In preclinical models involving mice, rats, and dogs, CA-4948 demonstrated good oral bioavailability and displayed over 90% tumor growth inhibition in relevant tumor models, correlating well with in vivo pharmacodynamic regulation.

MyD88, NF-κB, IRAK, Apoptosis, FLT

Tyrosine Kinase/Adaptors, Apoptosis, Angiogenesis, Immunology/Inflammation, NF-κB

2376354

C31H33N7O8S

663.7

S(=O)(=O)(O)C1=CC=C(C)C=C1.N(C(=O)C=1N=C(OC1)C=2C=C(C)N=CC2)C3=C(N=C4C(=C3)OC(=N4)N5CCOCC5)N6CC[C@@H](O)C6

-20°C

Ice Packs

Small Compound