EMT inhibitor-3 - CAS 2930726-89-7

EMT inhibitor-3 (compound 11i) is an epithelial-mesenchymal transition (EMT) inhibitor that effectively suppresses the proliferation, migration, and invasion of SK-N-SH neuroblastoma cells, with an IC50 value of 2.5 μM. It induces mitochondrial-mediated intrinsic apoptosis in tumor cells by enhancing the Bax/Bcl-2 protein expression ratio, promoting the release of cytochrome C from mitochondria, and activating caspase 9 and caspase 3. EMT inhibitor-3 is applicable for cancer research.

Bcl-2 Family, Caspase, Apoptosis, Cytochromes P450

Metabolism, Proteases/Proteasome, Apoptosis

2930630

C29H21F2N3O4Se

592.45

N#C[Se]CCCOC=1C=CC=2C=C(C(=O)OC2C1)C(=O)N3N=C(C=4C=CC(F)=CC4)CC3C5=CC=C(F)C=C5

-20°C

Ice Packs

Small Compound