EN171 - CAS 2191110-79-7

EN171, a covalent ligand, selectively binds to C38 and C96 on 14-3-3, intensifying 14-3-3's interactions with ERα, YAP, and TAZ. This action impairs both estrogen receptor and Hippo pathway transcriptional activities. Beyond serving as a molecular glue to augment native protein interactions, EN171 also functions as a covalent recruiter for 14-3-3 in heterobifunctional molecules. This facilitates the sequestration of nuclear neo-substrates, such as BRD4 and BLC6, into the cytosol.

Estrogen Receptor/ERR, Molecular Glues, Hippo pathway, Others

Endocrinology/Hormones, PROTAC, Stem Cells, Others

2191024

C17H22N2O

270.37

O=C(C=C)N1CCC2(C1)CN(CC=3C=CC=CC3)CC2

-20°C

Ice Packs

Small Compound