EN450 - CAS 793719-01-4

EN450 is a cysteine-responsive covalent molecular gel degrader of targeted NF-κB with antiproliferative and potentially anticancer activity, which acts through a dependence on Cullin E3 ligase and protease, and can be used to study leukemia.

Molecular Glues, NF-κB, E1/E2/E3 Enzyme

PROTAC, NF-κB, Ubiquitination

793719-01-4

0.9972

C11H13ClN2O3S

288.75

O=C(C=C)NC1=CC(=CC=C1Cl)S(=O)(=O)N(C)C

-20°C

Ice Packs

Small Compound