Endosidin-2 - CAS 1839524-44-5

Endosidin-2 is an exocyst inhibitor, a cell-permeable benzylidene benzoylhydrazine, that binds to the exocyst component of the 70 kDa (EXO70) subunit of the exocyst complex (Kd = 253 μM, EXO70A1) .Endosidin-2 disrupts protein translocation between the endosomes and plasma membrane, thereby facilitating translocation of proteins to the vesicle for degradation. It also inhibits recirculation of endocytosed transferrin to the plasma membrane in HeLa cells and targets multiple isoforms of mammalian EXO70, leading to dysregulation of exocytosis.Endosidin2 can be used as a tool molecule to study cytosolization.

Others

Others

1839475

0.9829

C15H12FIN2O3

414.17

COC1=CC(\C=N\NC(=O)C2=CC=CC(F)=C2)=CC(I)=C1O

-20°C

Ice Packs

Small Compound