Enpp-1-IN-19 - CAS 2738583-25-8

Enpp-1-IN-19 (compound 29f) is an orally active inhibitor of ENPP1 that effectively blocks cGAMP hydrolysis with an IC50 of 68 nM. It not only enhances anti-PD-L1 responses and curtails tumor growth in CT26 syngeneic models but also boosts STING-mediated type I interferon responses. Additionally, Enpp-1-IN-19 fosters immune memory and aids in preventing tumor recurrence [1].

PDE, STING

Metabolism, Immunology/Inflammation

2738583-25-8

C16H16N4O3S

344.39

C(C=1C=2C(C(=O)N(C)N1)=CC=CC2)C3=CC=C(NS(N)(=O)=O)C=C3

-20°C

Ice Packs

Small Compound