Enpp-1-IN-25 - CAS 3067908-20-4

Enpp-1-IN-25 (Compound 30) is an ENPP1 inhibitor with an IC50 of 8.05 nM and exhibits low oral bioavailability. By inhibiting cGAMP degradation, it effectively activates the intracellular STING pathway. Enpp-1-IN-25 can enhance immune cell infiltration and type I interferon response in the tumor microenvironment, thereby increasing the antitumor efficacy of anti-PD-L1 antibodies. It is applicable for research in cancer immunotherapy.

PD-1/PD-L1, STING, PDE

Metabolism, Cell Cycle/Checkpoint, Immunology/Inflammation, Apoptosis

3067884

C15H21N5O4S

367.423

O=S(=O)(N)NCC1(O)CCN(C=2N=CN=C3C(OC)=CC=CC32)CC1

-20°C

Ice Packs

Small Compound