Ent-8-iso-15 (S) -Prostaglandin F2α - CAS 214748-66-0

Isoprostanes are produced by the non-enzymatic, free radical peroxidation of phospholipid-esterified arachidonic acid. They have been used as biomarkers of oxidative stress, but they also have been found to have potent biological activity. ent-8-iso-15 (S) -Prostaglandin F2α (ent-8-iso-15 (S) -PGF2α) is a potent vasoconstrictor of porcine retinal and brain microvessels with EC50 values of 15 and 24 nM, respectively. This isoprostane is about ten-fold more potent than 8-iso-PGF2α in a whole blood platelet aggregation inhibition assay.

Others, Endogenous Metabolite

Others, Metabolism

214682

C20H34O5

354.48

C(/C=C\CCCC(O)=O)[C@@H]1[C@H](/C=C/[C@H](CCCCC)O)[C@@H](O)C[C@H]1O

-20°C

Ice Packs

Small Compound