Entacapone sodium salt - CAS 1047659-02-8

Entacapone sodium salt inhibits catechol-O-methyltransferase (COMT) with similar IC50 in different tissues including live, duodenum, kidney and lung, but entacapone is more active than tolcapone in those tissues. Entacapone (< 100 μM) is a potent inhibitor of α-syn and β-amyloid (Aβ) oligomerization and fibrillogenesis, and also protects against extracellular toxicity induced by the aggregation of both proteins in PC12 cells.Entacapone sodium salt is a specific, potent, peripherally acting catechol-O-methyltransferase (COMT) inhibitor with IC50 of 151 nM for PD treatment.

Others, Transferase

Others, Metabolism

1047659-02-8

C14H15N3NaO5

328.28

[Na].CCN(CC)C(=O)C(=C\c1cc(O)c(O)c(c1)N(=O)=O)\C#N

-20°C

Ice Packs

Small Compound