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Entrectinib - CAS 1108743-60-7

Entrectinib - CAS 1108743-60-7

MF-0019462-01

$36.16 USD
$36.16 USD
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Product Details

  • Bioactivity

    Entrectinib (RXDX-101) is a Trk, ROS1, and ALK inhibitor that inhibits TrkA, TrkB, TrkC, ROS1, and ALK (IC50=1/3/5/12/7 nM) with oral activity and blood-brain-barrier penetration. Entrectinib exhibits both antitumor and CNS activity.

  • Target

    ROS Kinase, Autophagy, ROS, ALK, Trk receptor

  • Related Pathways

    Tyrosine Kinase/Adaptors, Immunology/Inflammation, Angiogenesis, Autophagy

  • CAS Number

    1108676

  • Purity

    0.9961

  • Molecular Formula

    C31H34F2N6O2

  • Molecular Weight

    560.64

  • SMILES

    N(C(=O)C1=C(NC2CCOCC2)C=C(C=C1)N3CCN(C)CC3)C=4C=5C(NN4)=CC=C(CC6=CC(F)=CC(F)=C6)C5

  • Storage Temperature

    -20°C

  • Shipping Conditions

    Ice Packs

  • Category

    Small Compound