EP2 receptor antagonist-3 - CAS 1799626-16-6

EP2 receptor antagonist-3 is a selective antagonist of the EP2 receptor, with an IC50 of 8 nM determined in the hEP2 SPA assay and an IC50 of 50 nM in the hEP2 cAMP assay. It enhances macrophage-mediated clearance of Amyloid-β plaques. In CD-1 mice, it shows moderate clearance and good exposure, and exhibits good central nervous system (CNS) exposure in both mice and rats. EP2 receptor antagonist-3 is applicable for research in Alzheimer's disease.

Prostaglandin Receptor, Beta Amyloid

Immunology/Inflammation, Neuroscience, GPCR/G Protein

1799604

C23H19ClFN3O2

423.87

O=C1C=C(C=CN1)CN2CC3=CC(=CC(Cl)=C3OCC2)N4C=CC=5C=C(F)C=CC54

-20°C

Ice Packs

Small Compound