Epothilone B - CAS 152044-54-7

Epothilone B (EPO 906) is a compound isolated from the myxobacterium Sorangium cellulosum. Similar to paclitaxel, patupilone induces microtubule polymerization and stabilizes microtubules against depolymerization conditions. In addition to promoting tubulin polymerization and stabilization of microtubules, this agent is cytotoxic for cells overexpressing P-glycoprotein, a characteristic that distinguishes it from the taxanes. Patupilone may cause complete cell-cycle arrest.

Apoptosis, Microtubule Associated, Antifungal, Antibacterial, Antibiotic

Cytoskeletal Signaling, Apoptosis, Microbiology/Virology

151983

0.9984

C27H41NO6S

507.68

C[C@H]1CCC[C@@]2(C)O[C@H]2C[C@H](OC(=O)C[C@H](O)C(C)(C)C(=O)[C@H](C)[C@H]1O)C(\C)=C\c1csc(C)n1

-20°C

Ice Packs

Small Compound