Eptapirone fumarate - CAS 179756-85-5

Eptapirone, also known as F11440, is a potent 5HT (1A) receptor agonist with marked anxiolytic and antidepressant potential. The affinity of F 11440 for 5-HT1A binding sites (pKi, 8.33) was higher than that of buspirone (pKi, 7.50), and somewhat lower than that of flesinoxan (pKi, 8.91) . In vivo, F 11440 was 4- to 20-fold more potent than flesinoxan, and 30- to 60-fold more potent than buspirone, in exerting 5-HT1A agonist activity at pre- and postsynaptic receptors in rats (measured by, for example, its ability to decrease hippocampal extracellular serotonin (5-HT) levels and to increase plasma corticosterone levels, respectively) .

5-HT Receptor, Others

Neuroscience, GPCR/G Protein, Others

179666

C20H27N7O6

461.479

OC(=O)\C=C\C(O)=O.Cn1c(=O)cnn(CCCCN2CCN(CC2)c2ncccn2)c1=O

-20°C

Ice Packs

Small Compound