Equisetin - CAS 57749-43-6

Equisetin, an N-methylserine-derived acyl tetramic acid isolated from the terrestrial fungus Fusarium equiseti NRRL 5537, functions as a Quorum-sensing inhibitor (QSI) that specifically attenuates QS-regulated virulence phenotypes in P. aeruginosa, presenting a potent lead for treating P. aeruginosa infections without hindering bacterial growth. This tetramate-containing natural product possesses antibiotic and cytotoxic properties, effectively inhibiting the growth of Gram-positive bacteria and HIV-1 integrase activity, yet it does not impact Gram-negative bacteria.

Others, STAT, AMPK, Reactive Oxygen Species, HIV Protease, Dehydrogenase, Antibiotic, Antibacterial

Metabolism, Proteases/Proteasome, Chromatin/Epigenetic, NF-κB, Others, Stem Cells, Microbiology/Virology, PI3K/Akt/mTOR signaling, JAK/STAT signaling, Immunology/Inflammation

57700

C22H31NO4

373.49

[H][C@@]12C[C@H](C)CC[C@@]1([H])[C@@](C)([C@H](\C=C\C)C=C2)C(\O)=C1\C(=O)[C@H](CO)N(C)C1=O

-20°C

Ice Packs

Natural Product