ER-27319 - CAS 201010-95-9

ER-27319, an acridone derivative, serves as a potent and selective inhibitor of spleen tyrosine kinase (SYK), effectively impeding both the tyrosine phosphorylation and enzymatic activity of SYK. With an inhibitory concentration (IC50) of 10 μM, this compound suppresses the release of allergic mediators from human and rat mast cells triggered by antigens, making it useful for allergy research [1] [2].

Syk

Tyrosine Kinase/Adaptors, Angiogenesis

200906

C20H22N2O5

370.4

C(C(O)=O)(O)=O.C(CCN)N1C=2C(C(=O)C=3C1=CC=CC3)=CC=C(C)C2C

-20°C

Ice Packs

Small Compound