ERβ agonist-1 - CAS 2412715-30-9

ERβagonist-1 (Compound 8) functions as a dual-active selective ERβ agonist (EC50: 46.8 nM) and an AR antagonist (IC50: 1555 nM) . By binding to ERβ, it activates its signaling pathways while simultaneously inhibiting AR activity. Retaining selective ERβ agonist activity in mouse models, ERβagonist-1 is applicable in prostate cancer research.

Estrogen Receptor/ERR, Androgen Receptor

Endocrinology/Hormones

2412676

C25H36O2

368.55

C(CCC(C)C)[C@@]12C(=C3[C@](C)(CC1)C=4C(CC3)=C(C)C(O)=CC4)C[C@@H](O)C2

-20°C

Ice Packs

Small Compound