ER covalent antagonist-1 - CAS 2757498-74-9

ER covalent antagonist-1 (Compound 39D) acts as an antagonist of the estrogen receptor α (ERα) . This compound inhibits the proliferation of ERα-positive MCF-7 cells with an IC50 of 0.98 μM, induces cell cycle arrest at the G0/G1 phase, and triggers apoptosis. Additionally, ER covalent antagonist-1 demonstrates antitumor activity in mouse models.

Estrogen Receptor/ERR, Apoptosis

Apoptosis, Endocrinology/Hormones

2757415

C33H32N2O5S

568.683

O(C1=C(C(=O)C2=CC=CC=C2)SC=3C1=CC=C(O)C3)C4=CC=C(OC5CN(C/C=C/C(=O)N6CCCCC6)C5)C=C4

-20°C

Ice Packs

Small Compound