Erastin2 - CAS 1695533-44-8

Erastin2 is a ferroptosis inducer and inhibitor of the system xc- cystine/glutamate transporter.[1][2] It inhibits glutamate release in CCF-STTG1 cells (IC50 = 0.0035 &#181M) and induces cell death in HAP1 cells at 5 &#181M, an effect blocked by ferrostatin-1 or deferoxamine.[1][2] Erastin2 also induces ferroptotic cell death in HT-1080 cells (EC50 = 0.15 &#181M), an effect blocked by β-mercaptoethanol (EC50 > 20 &#181M) .[3] Additionally, it increases lipid peroxidation in HT-1080 cells at 1 &#181M.

Ferroptosis

Apoptosis

1695481

0.9963

C36H35ClN4O4

623.14

CC(C)Oc1ccc(cc1-n1c(CN2CCN(CC2)C(=O)COc2ccc(Cl)cc2)nc2ccccc2c1=O)-c1ccccc1

-20°C

Ice Packs

Small Compound