ERBB agonist-1 - CAS 930856-19-2

ERBB agonist-1 (Compound EF-1) is an ERBB4 agonist (EC50=10.5 μM) that induces ERBB4 receptor dimerization and phosphorylation of Akt and ERK1/2. It exhibits cardioprotective effects in mouse models and prevents myocardial fibrosis.

Akt, EGFR, ERK

PI3K/Akt/mTOR signaling, Angiogenesis, JAK/STAT signaling, MAPK, Tyrosine Kinase/Adaptors, Cytoskeletal Signaling

930835

0.999

C24H25N3O2S

419.54

O=C1C=2C=CC=CC2N=C(SC(C(=O)NC3CC3)C=4C=CC=CC4)N1C5CCCC5

-20°C

Ice Packs

Small Compound