ERK1/2 inhibitor 9 - CAS 2169302-75-2

ERK1/2 Inhibitor 9 (Probe 1), a covalent antagonist of ERK1/2, exhibits sub-micromolar efficacy in cellular assays (A375 GI50=0.47 μM) and facilitates the reduction of phospho-ERK1/2 levels. When conjugated with trans-cyclo-octene (TCO) and Tz-Thalidomide (tetrazine-tagged Thalidomide), it forms the corresponding ERK-CLIPTAC, promoting targeted ERK1/2 degradation [1].

ERK

MAPK

2169225

C31H32ClN7O3

586.08

O=C(OC1CCC=CCCC1)NCCC#CC2=NC=CC(=C2)NC3=NC=C(Cl)C(=N3)NC=4C=CC=CC4NC(=O)C=C

-20°C

Ice Packs

Small Compound