ERK2-IN-6 - CAS 2095713-33-8

ERK2-IN-6 (Compound 20) is a highly selective ERK1/2 inhibitor with an IC50 value of 7.9 nM for ERK2. It effectively inhibits the proliferation of BRAFV600E mutant cells, with an IC50 of 250 nM in A375 cells. ERK2-IN-6 shows potential for research in solid tumors such as melanoma with BRAF mutations.

ERK

MAPK

2095672

C28H30ClN5O3

520.02

O=C1C=2C=C(C=CC2CN1CC(=O)NC(C=3C=CC=CC3)(C)C)C4=NC(=NC=C4Cl)NC5CCOCC5

-20°C

Ice Packs

Small Compound