ERRα antagonist-1 - CAS 1072145-33-5

ERRα antagonist-1 (ERR+/- antagonist-1) is a high-affinity, selective antagonist of the estrogen-related receptor α (ERRα) . It effectively prevents the interaction of ERRα with both Proliferator-activated Receptor γ Coactivator-1α (PGC-1α) and PGC-1β, displaying IC50 values of 170 nM and 180 nM, respectively. Notably, ERRα antagonist-1 does not interfere with the interactions involving ERRβ or ERRγ and the PGC-1α and PGC-1β coactivators. Furthermore, it does not affect the interaction between either ERα or ERβ and PGC-1α or SRC-1.

Estrogen Receptor/ERR, Estrogen/progestogen Receptor

Endocrinology/Hormones

1072145-33-5

>99.99%

C21H19N3S2

377.53

C1CN=C(S1)N1CCS\C1=N/C1c2ccccc2C=Cc2ccccc12

-20°C

Ice Packs

Small Compound