Ethacrynic acid - CAS 58-54-8

Ethacrynic acid (Edecrin) is a nonsulfonamide loop diuretic that inhibits the activity of the Na+/K+/2Cl- cotransporter NKCC2 in the thick ascending limb of the loop of Henle. It also inhibits glutathione S-transferase and Wnt signalling, producing cytotoxicity in chronic lymphocytic leukaemia cells and other tumour cells.

NF-κB, Calcium Channel, Wnt/beta-catenin, GST, NO Synthase

Membrane transporter/Ion channel, Cytoskeletal Signaling, Immunology/Inflammation, Metabolism, Oxidation-Reduction, NF-κB, Stem Cells

-4

>99.99%

C13H12Cl2O4

303.14

CCC(=C)C(=O)C1=CC=C(OCC(O)=O)C(Cl)=C1Cl

-20°C

Ice Packs

Small Compound