(±) -Evodiamine - CAS 518-18-3

(±) -Evodiamine is an alkaloid isolated from Evodiae fructus and a topoisomerase I inhibitor. It also inhibits adipocyte differentiation and diabetes by downregulating IGF-1/HIF-1α and IL-6/STAT pathways. As an inhibitor of NF-κB activation, it suppresses invasion, promotes apoptosis, and inhibits TNF-induced Akt activation.

STAT, IL Receptor, Apoptosis, IGF-1R, Topoisomerase, HIF

Chromatin/Epigenetic, Tyrosine Kinase/Adaptors, JAK/STAT signaling, Angiogenesis, DNA Damage/DNA Repair, Immunology/Inflammation, Stem Cells, Apoptosis

497

0.99904

C19H17N3O

303.36

CN1C2C3=C(C=4C(N3)=CC=CC4)CCN2C(=O)C=5C1=CC=CC5

-20°C

Ice Packs

Natural Product