EVT0185 - CAS 2588489-03-4

EVT0185 is an orally active ATP citrate lyase (ACLY) inhibitor. In the liver, it is converted by SLC27A2 into a CoA thioester, which interacts with the CoA binding site of ACLY. EVT0185-CoA inhibits ACLY activity with an IC50 of 2.5 μM. It mimics the immune and antitumor effects seen with ACLY gene deletion. Additionally, EVT0185 elevates levels of tumor-infiltrating B cells and the chemokine CXCL13. It is applicable in cancer research, including hepatocellular carcinoma (HCC) .

ATP Citrate Lyase

Metabolism

2588489-03-4

C22H34O4

362.5

O=C(O)C(C)(C)CCCCC1=CC=C(C=C1)CCCCC(C(=O)O)(C)C

-20°C

Ice Packs

Small Compound