EW-7195 - CAS 1352609-28-9

EW-7195 is a selective and potent inhibitor of ALK5 (TGFβR1) with an IC50 value of 4.83 nM.EW-7195 has an affinity for ALK5 that is more than 300-fold higher than that of p38α.EW-7195 has an inhibitory effect on TGF-β1-induced Smad signaling, epithelial mesenchymal transition (EMT), and breast cancer metastasis to the lungs.

P38 MAPK, ALK, TGF-beta/Smad

MAPK, Tyrosine Kinase/Adaptors, Angiogenesis, Stem Cells

1352572

0.9998

C23H18N8

406.44

Cc1cccc(n1)-c1[nH]c(CNc2cccc(c2)C#N)nc1-c1ccc2ncnn2c1

-20°C

Ice Packs

Small Compound