F-1394 - CAS 162490-89-3

F-1394 is an acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor. F-1394 both prevents the formation of atherosclerosis and accelerates its regression without affecting the serum TC level, indicating that F-1394 acts directly on the arterial wall. F-1394 significantly reduced neointimal thickening and the extent of macrophages in lesions without affecting serum cholesterol levels. In vitro, F-1394 attenuated foam cell formation in mouse peritoneal macrophages.

Acyltransferase, Others

Others, Metabolism

162398

C33H61N3O6

595.85

C(NCCC(O[C@@H]1[C@@H](NC(N(CCCCCCCCC)CC(C)(C)C)=O)CCCC1)=O)(=O)[C@H]2C(C)(C)COC(C)(C)O2

-20°C

Ice Packs

Small Compound