F44-A13 - CAS 1338190-14-9

F44-A13 is an orally active, highly selective farnesoid X receptor (FXR) antagonist with an IC50 value of 1.1 μM. It optimizes cholesterol metabolism and reduces activity by inducing CYP7A1 expression, lowering cholesterol, triglycerides, and low-density lipoprotein cholesterol (LDL-C) levels in mouse models. F44-A13 is applicable for studying metabolic diseases associated with lipid disorders [1].

PPAR, Cytochromes P450, FXR, Retinoid Receptor, ROR

Metabolism, DNA Damage/DNA Repair

1338190-14-9

C28H40N4O5S

544.71

C(N(CC1CC1)C(NC(C)(C)C)=O)C2=C(OS(=O)(=O)C3=CC=C(NC(C)=O)C=C3)C=C(N(CC)CC)C=C2

-20°C

Ice Packs

Small Compound