FAK-IN-24 - CAS 3062175-62-3

FAK-IN-24 (Compound 9f) is a potent FAK inhibitor with an IC50 of 0.815 nM. It induces DNA damage and apoptosis, and exhibits activity against glioblastoma. FAK-IN-24 effectively inhibits proliferation of glioblastoma cell lines U87-MG (IC50= 15 nM) and U251 (IC50= 20 nM), and suppresses tumor growth in U87-MG xenograft models.

FAK, Apoptosis

Cytoskeletal Signaling, Tyrosine Kinase/Adaptors, Angiogenesis, Apoptosis

3062110

C39H45Cl2F3N8O3

801.728

O=C(OCCN1CCN(C2=CC=C(C=C2)NC3=NC=C(C(=N3)NC=4C=CC=CC4C(=O)NC)C(F)(F)F)CC1)CCCC5=CC=C(C=C5)N(CCCl)CCCl

-20°C

Ice Packs

Small Compound