FAK-IN-26 - CAS 2801785-12-4

FAK-IN-26 is a blood-brain barrier-penetrating inhibitor of Focal Adhesion Kinase (FAK) with an IC50 of 0.87 nM. It significantly reduces tumor cell viability, cancer stem cell activity, and cell migration in A549 and SKOV-3 cell lines. FAK-IN-26 exhibits potent anticancer activity, achieving tumor inhibition rates of 59.15% and 57.9% in A549 and SKOV-3 tumor mouse models, respectively.

FAK

Cytoskeletal Signaling, Tyrosine Kinase/Adaptors, Angiogenesis

2801769

C20H19BrFN5O2

460.3

O=C(NC)C=1C=CC=CC1NC2=NC(=NC=C2Br)NC3=CC=C(OCCF)C=C3

-20°C

Ice Packs

Small Compound