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Molfinity

FAK PROTAC B5 - CAS 2471525-44-5

FAK PROTAC B5 - CAS 2471525-44-5

MF-0154648-01

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Product Details

  • Bioactivity

    Compound B5 (FAK PROTAC B5) is a FAK PROTAC degrader exhibiting potent FAK degradation and antiproliferative activities, with an IC50 of 14.9 nM. It also shows excellent plasma stability, moderate membrane permeability, and inhibits cell migration and invasion [1].

  • Target

    PROTACs, FAK, Others

  • Related Pathways

    Tyrosine Kinase/Adaptors, Angiogenesis, Others, PROTAC, Cytoskeletal Signaling

  • CAS Number

    2471476

  • Molecular Formula

    C41H43ClN10O7

  • Molecular Weight

    823.3

  • SMILES

    CNC(=O)c1ccccc1Nc1nc(Nc2ccc(cc2OC)N2CCN(CCCCC(=O)Nc3cccc4C(=O)N(C5CCC(=O)NC5=O)C(=O)c34)CC2)ncc1Cl

  • Storage Temperature

    -20°C

  • Shipping Conditions

    Ice Packs

  • Category

    PROTAC