Famitinib malate - CAS 1256377-67-9

Famitinib malate (SHR1020) is an orally active multi-targeted kinase inhibitor that effectively inhibits the activity of c-kit, VEGFR-2, and PDGFRβ with IC50 values of 2.3 nM, 4.7 nM, and 6.6 nM, respectively. It induces cell apoptosis and demonstrates potent antitumor activity in human gastric cancer cells and xenografts, making it a valuable compound for cancer research.

Others, PDGFR, Apoptosis, VEGFR

Tyrosine Kinase/Adaptors, Others, Apoptosis, Angiogenesis

1256301

C27H33FN4O7

544.57

[C@H](CC(O)=O)(C(O)=O)O.C(=C\1/C=2C(NC1=O)=CC=C(F)C2)\C3=C(C)C4=C(N3)CCN(CCN(CC)CC)C4=O

-20°C

Ice Packs

Small Compound