Faridoxorubicin - CAS 1841402-73-0

Faridoxorubicin (AVA-6000) is a prodrug that targets fibroblast activation protein alpha (FAPα) . It releases active doxorubicin through FAPα-mediated cleavage, enhancing drug exposure within tumors while reducing cardiac toxicity. Faridoxorubicin holds potential for research in solid tumors, such as liver metastases from colorectal cancer.

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1841329

C41H44N4O14

816.81

OC=1C2=C([C@@H](O[C@H]3C[C@H](NC(=O)[C@H]4N(C([C@H](NC(=O)C=5C=CN=CC5)C)=O)CCC4)[C@H](O)[C@H](C)O3)C[C@@](C(CO)=O)(O)C2)C(O)=C6C1C(=O)C=7C(C6=O)=C(OC)C=CC7

-20°C

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