Fasudil dihydrochloride - CAS 203911-27-7

Fasudil dihydrochloride, also known as HA-1077 and AT877, is a nonspecific inhibitor of RhoA/ROCK. Fasudil dihydrochloride exhibits inhibitory effects on protein kinases including ROCK1 (Ki = 0.33 μM), ROCK2 (IC50 = 0.158 μM), PKA (IC50 = 4.58 μM), PKC (IC50 = 12.30 μM), and PKG (IC50 = 1.650 μM), while also acting as a potent Ca2+ channel blocker and vasodilator, providing a multifunctional pharmacological tool for vascular, cardiovascular, and cellular signaling research.

ROCK, Rho, PKA, PKC

Chromatin/Epigenetic, Tyrosine Kinase/Adaptors, Cytoskeletal Signaling, Cell Cycle/Checkpoint, Stem Cells

203877

0.9986

C14H19Cl2N3O2S

364.29

O=S(C1=CC=CC2=C1C=CN=C2)(N3CCNCCC3)=O.Cl.Cl

-20°C

Ice Packs

Small Compound