Fasudil mesylate - CAS 1001206-62-7

Fasudil mesylate (HA-1077; AT877) is a nonspecific, orally active inhibitor of RhoA/ROCK, exhibiting additional inhibitory effects on protein kinases with a K i of 0.33 μM for ROCK1. It shows IC 50 values of 0.158 μM for ROCK2, and 4.58 μM, 12.30 μM, and 1.650 μM for PKA, PKC, and PKG, respectively. Furthermore, Fasudil mesylate acts as a potent Ca 2+ channel antagonist and vasodilator, enhancing its pharmacological profile [1] [2] [3] [4] [5] [6].

PKA, PKC, Autophagy, Calcium Channel, ROCK

Cell Cycle/Checkpoint, Stem Cells, Autophagy, Chromatin/Epigenetic, Membrane transporter/Ion channel, Metabolism, Cytoskeletal Signaling, Tyrosine Kinase/Adaptors

1001206-62-7

C15H21N3O5S2

387.47

S(C)(=O)(=O)O.S(=O)(=O)(C=1C2=C(C=CC1)C=NC=C2)N3CCCNCC3

-20°C

Ice Packs

Small Compound