Fazarabine - CAS 65886-71-7

Fazarabine, also known as Kymarabine, is an orally-active pyrimidine analogue of an aza-substituted cytidine in which the ribose moiety is replaced by an arabinose sugar. Similar in action to cytarabine, fazarabine is phosphorylated by deoxycytidine kinase to a triphosphate form which competes with thymidine for incorporation into DNA; its incorporation into DNA inhibits DNA synthesis, resulting in tumor cell death and tumor necrosis. The presence of deoxycytidine kinase in a tumor is a determinant of tumor sensitivity to this drug.

Others

Others

65808

C8H12N4O5

244.2

O[C@@H]1[C@@H](O[C@H](CO)[C@H]1O)N2C(=O)N=C(N)N=C2

-20°C

Ice Packs

Small Compound