FC 11 - CAS 2271035-37-9

FC 11 is a highly potent focal adhesion Ki nase (FAK) PROTAC®Degrader (DC50 values are 40 to 370 pM depending on cell line), which is composed of the FAK inhibitor PF 562217 joined by a linker to the cereblon-binding ligand Pomalidomide. The effects of FC 11 are reversible upon compound wash out. FC 11 also degrades autophosphorylated FAK (pFAKtyr397), displaying near complete degradation after 3 hours at 100 nM in TM3 cells.

PROTACs, FAK

Cytoskeletal Signaling, Angiogenesis, Tyrosine Kinase/Adaptors, PROTAC

2270989

C41H42F3N13O9S

949.91

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-20°C

Ice Packs

PROTAC