FC-14367 - CAS 3066893-65-7

FC-14367 is a PROTAC degrader targeting the HIV-1Nef protein. It forms a ternary complex by binding Nef with CereblonE3 ubiquitin ligase, inducing ubiquitination of Nef and its subsequent proteasomal degradation. This restores cell surface CD4 and MHC-I expression, inhibiting HIV-1 replication. FC-14367 is useful for research on HIV infection and AIDS.

HIV Protease, PROTACs

PROTAC, Microbiology/Virology, Proteases/Proteasome

3066821

C38H35ClFN7O6

740.18

O=C1NC(=O)C(N2C(=O)C=3C=CC=C(OCC(=O)N4CCC(C5=NN(C(O)=C5CCC6=CC=C(F)C=C6)C7=NC=8C=C(Cl)C=CC8N7)CC4)C3C2)CC1

-20°C

Ice Packs

PROTAC